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PERRYVILLE, Mo. - A school bus driver was killed in a crash Tuesday morning in Perryville, Missouri. He has been identified as 72-year-old James Kennedy. The Missouri State Highway Patrol said the crash between a school bus and a box truck happened in the 1400 block of Highway K near Bluebird Lane. MSHP said no [...]

ST. LOUIS - St. Louis City residents are still struggling to get their garbage picked up and they're not getting any answers from the city. They said it's creating a horrible mess just outside their homes, and the mess is encouraging others to come into their neighborhood and dump their garbage. Leslie Herron called the [...]

Illinois State Representative Amy Elik and the Wood River Police Department will host a drive-through prescription drug drop-off event Wednesday, September 7.

A man was shot and killed just south of downtown St. Louis early Tuesday morning.

ST. LOUIS - A brick building in south St. Louis was fully engulfed in flames Tuesday morning. Firefighters responded to the 3800 block of South Compton in south St. Louis at about 5 a.m. It is unknown at this time what started the fire. FOX 2's Nissan Rogue Runner reporter was at the scene. FOX [...]

A key player charged in the murder-for-hire plot that left the grandson of the owner of Sweetie Pie’s Restaurant dead goes on trial Tuesday, September 6. 

Heaven Scent Bakery in O'Fallon, Missouri announced is closing its doors after nearly 30 years in business.

A suspect wanted for the murder of his wife was in police custody Monday, according to the Hazelwood Police Department.

In dripping black wetsuits and scuba masks, standing in the middle of a southern Missouri river last month, a state herpetologist and two zookeepers hugged each other and cheered.

Jack Flaherty pitched five effective innings for St. Louis in his first big league game since late June, but the NL Central-leading Cardinals had their four-game winning streak stopped in a 6-0 loss to Joey Meneses and the Washington Nationals.

The governor is calling the General Assembly back to Jefferson City to reauthorize tax credits for farmers and to lower the state's income tax rate. That special session was set to start Tuesday. Last week, House and Senate Leadership said they needed more time to form a plan and would wait until the veto session in the middle of the month to convene. 

Some people prefer to spend their Labor Day in front of the grill while others like to enjoy outdoor activities. But a special group of competitors spent the day making smooth moves indoors.

If one had the day off Monday, they had the chance to attend annual festivals in the area, as well as numerous first-time events.

Springfield police say an officer shot and killed a man who was carrying a rifle in a parking lot.

Travelers going through St. Louis-Lambert International Airport on Labor Day face headaches amidst a slew of delays and cancellations nationwide.

It has been a less-than-perfect holiday weekend as an orphaned weather system has been drifting through the bi-state area since Friday.

Stacker compiled a list of the counties with the oldest homes in Missouri using data from the U.S. Census Bureau.

ST. CLAIR COUNTY, Ill. - A man was struck and killed early Monday morning in St. Clair County, Illinois on I-64. Illinois State Police said a blue Acura was driving eastbound on I-64 just after 12 a.m. when it "hydroplaned and struck the left guardrail and concrete bridge rail." The driver then exited the Acura [...]

ST. LOUIS - New St. Louis City Health Director Dr. Mati Hlatshwayo Davis said when it comes to Monkeypox, she's focusing on education and is trying to steer the community away from stigmatizing victims of the virus. She said education is a key component of the battle against the disease. She also said one of the [...]

ST. LOUIS - MetroLink is still making adjustments because of flood damage that occurred in late July. Starting Monday, blue line trains will only operate from Forest Park to Shrewsbury. Riders will have to transfer to red line trains at the Forest Park-Debaliviere station to continue eastbound. Blue line trains will operate every 20 minutes. Red line trains [...]