New Chronotherapy Research Could Eliminate Daily Injections for People With Rheumatoid or Juvenile Arthritis
ST. LOUIS - With nearly 1.5 million people suffering from rheumatoid and juvenile arthritis in the United States, researchers at Shriners Children’s St. Louis have discovered a new revolutionary way to potentially minimize flare-ups and symptoms while preventing the progression of the disease. Shriners Children’s St. Louis Director of Research Dr. Farshid Guilak recently published findings on a revolutionary new method of “chronotherapy,” the administration of drugs based on the body’s circadian rhythm, potentially changing the way the condition is treated in the future. Circadian rhythm refers to the body's 24-hour clock which is regulated by the brain and responds to light. Using a combination of synthetic biology and tissue engineering, Dr. Guilak’s research team developed circadian-based gene circuits, termed “chronogenetics,” that can be programmed into stem cells that, once implanted in the body, align with a patient’s